Correlation of Saliva Codeine Concentrations with Plasma Concentrations after Oral Codeine Administration
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چکیده
منابع مشابه
Correlation of saliva codeine concentrations with plasma concentrations after oral codeine administration.
A clinical study was designed to determine if there was a predictable relationship between saliva and plasma codeine concentrations. Drug-free volunteers (n = 17) were administered a 30-mg dose of liquid codeine phosphate. Plasma and saliva specimens were collected at various times for 24 h after administration. Plasma and saliva were analyzed for codeine and morphine by positive-ion chemical i...
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THE quantitative and serial changes that occur in serum glutamic-oxaloacetic transaminase (SGOT) activity during the course of a myocardial infarction are well recognized. Changes in SGOT activity have been observed in other diseases such as hepatitis and pancreatitis (Wroblewski and LaDue, '955; Chinsky, Shmagranoff and Sherry, 1956) and after the administration of drugs such as chlorpromazine...
متن کاملOpioid disposition in human sweat after controlled oral codeine administration.
BACKGROUND Characterization of opioid excretion in sweat is important for accurate interpretation of sweat tests in drug treatment, criminal justice, and workplace drug testing programs. METHODS Participants (n=20) received placebo, 3 low (60 mg/70 kg) or 3 high (120 mg/70 kg) codeine sulfate doses (used as a model for opioid excretion) within 1 week. Codeine and metabolites in sweat were col...
متن کاملPlasma and oral fluid pharmacokinetics and pharmacodynamics after oral codeine administration.
BACKGROUND The ease, noninvasiveness, and safety of oral fluid collection have increased the use of this alternative matrix for drugs-of-abuse testing; however, few controlled drug administration data are available to aid in the interpretation of oral fluid results. METHODS Single oral codeine doses (60 and 120 mg/70 kg) were administered to 19 volunteers. Oral fluid and plasma were analyzed ...
متن کاملPlasma concentrations and clinical effects of lorazepam after oral administration.
The relation between plasma concentrations and properties of lorazepam administered orally as premedication was studied in patients undergoing minor surgery. The drug was found to be reliably absorbed in most subjects producing plasma concentrations similar to those reported after injection. Effective concentrations were obtained within 30-60 min, maintained for 4-6 h and were closely related t...
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ژورنال
عنوان ژورنال: Journal of Analytical Toxicology
سال: 1999
ISSN: 0146-4760,1945-2403
DOI: 10.1093/jat/23.6.452